LIF and the heart: Just Another Brick in the Wall?

LIF and the heart: just another brick in the wall?

Multiple studies have shown that the cytokine leukemia inhibitory factor (LIF) is protective of the myocardium in the acute stress of ischemia-reperfusion. All three major intracellular signaling pathways that are activated by LIF in cardiac myocytes have been linked to actions that protect against oxidative stress and cell death, either at the level of the mitochondrion or via nuclear transcri...

LipidII: Just Another Brick in the Wall?

Nearly all bacteria contain a peptidoglycan cell wall. The peptidoglycan precursor molecule is LipidII, containing the basic peptidoglycan building block attached to a lipid. Although the suitability of LipidII as an antibacterial target has long been recognized, progress on elucidating the role(s) of LipidII in bacterial cell biology has been slow. The focus of this review is on exciting new d...

MAIT cells: not just another brick in the wall.

The link between gut and joint inflammation in spondyloarthritis (SpA) is well established, in particular in ankylosing spondylitis (AS) and peripheral SpA. In 1995, Mielants et al discovered that almost 50% of patients with SpA have subclinical gut inflammation, of which a fraction develops Crohn’s disease over time. Recent studies clearly showed that the onset of disease and disease severity ...

Another brick in the wall.

Sao Paulo Med J/Rev Paul Med 2002; 120(2):35. The history of lung cancer spans many years, and over recent decades excision of tumors has been considered as the only effective treatment. In 1933 Graham performed the first successful pneumonectomy due to lung cancer. In 1937 Ochsner and DeBakey first concluded that smoking is a cause of lung cancer. This important observation was confirmed by Do...

MicroRNA-21 in colorectal cancer: "Just another brick in the wall"?